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Logo: Institute of Microwave and Wireless Systems
Logo Leibniz Universität Hannover
Logo: Institute of Microwave and Wireless Systems
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Tumor Treating Fields

Fig 1: Schematic view on TTF-Electrodes attached to human head

Tumor Treating Fields (TTF) are a treatment method for different malignant tumors. This far TTF applications have been authorized for treatment of brain tumors like glioblastoma. Thereby, several electrodes are applied similarly to a hat on the human skull and induce alternating electric fields within the brain, like schematically shown in Figure 1. Tuned to proper field amplitudes, frequency and polarization the electric fields inhibit the propagation of tumor cells which are mitotically active. Compared to other tumor treatment methods, a huge advantage of TTF is that it has almost no effect on healthy cells and the whole organism, resulting in no side effects for the afflicted. Although several studies show the efficacy of TTF, the discussion of the mechanisms of action of TTF is not finally settled. A fundamental understanding of the mechanisms of action would possibly allow the development of even more effective applications for tumor treatment.

Research at Institute of Microwave and Wireless Systems

At the Institute for Microwave and Wireless Systems the mechanisms of action of the TTF method are systematically investigated. Therefore electromagnetic simulation software is used and electric equivalent circuit models are developed for tumor cells in order to investigate thermal effects of the TTF method and to find proper field settings regarding e.g. field amplitude and frequency. Additionally, different TTF application setups are developed for various in vivo and in vitro experiments for the validation of theoretical results.

Our cooperation partners

In cooperation with the Institute of biophysics of Leibniz University of Hannover and the neurologic clinic of the Hanover Medical School various different in vitro and in vivo experiments are conducted in the frame of TTF research. The three cooperation partners complement each other with their expertise on the different major fields important for TTF research.

Research at Institute of Microwave and Wireless Systems

At the Institute for Microwave and Wireless Systems the mechanisms of action of the TTF method are systematically investigated. Therefore electromagnetic simulation software is used and electric equivalent circuit models are developed for tumor cells in order to investigate thermal effects of the TTF method and to find proper field settings regarding e.g. field amplitude and frequency. Additionally, different TTF application setups are developed for various in vivo and in vitro experiments for the validation of theoretical results.

Our cooperation partners

In cooperation with the Institute of biophysics of Leibniz University of Hannover and the neurologic clinic of the Hanover Medical School various different in vitro and in vivo experiments are conducted in the frame of TTF research. The three cooperation partners complement each other with their expertise on the different major fields important for TTF research.